| Date | Location | Result | |
| 4/10/21 | Hutchinson, KS | Holmes 71, Vincennes University 66 | Box score |
| 4/9/21 | Carterville, IL | John A. Logan 77, Vincennes University 68 | Box score |
| 4/7/21 | Vincennes, IN | Vincennes University 79, Shawnee 49 | Box score |
| 4/5/21 | Vincennes, IN | Vincennes University 73, Kaskaskia 47 | Box score |
| 4/1/21 | Vincennes, IN | Vincennes University 62, Wabash Valley 48 | Box score |
| 3/27/21 | Centralia, IL | Vincennes University 69, Kaskaskia 58 | Box score |
| 3/20/21 | Ullin, IL | Vincennes University 69, Shawnee 66 | Box score |
| 3/17/21 | Carterville, IL | John A. Logan 72, Vincennes University 58 | Box score |
| 3/13/21 | Vincennes, IN | Vincennes University 74, Lincoln Trail 51 | Box score |
| 3/10/21 | Mattoon, IL | Vincennes University 78, Lake Land 69 | Box score |
| 3/6/21 | Vincennes, IN | Vincennes University 76, Olney Central 63 | Box score |
| 3/3/21 | Mt Carmel, IL | Vincennes University 61, Wabash Valley 56 | Box score |
| 2/27/21 | Belleville, IL | Southwestern Illinois 69, Vincennes University 60 | Box score |
| 2/2/21 | Vincennes, IN | Vincennes University 79, Kaskaskia 64 | Box score |
| 2/22/21 | Vincennes, IN | Vincennes University 68, Shawnee 58 | Box score |
| 2/22/21 | Godfrey, IL | Vincennes University 84, Lewis and Clark 61 | Box score |
| 2/11/21 | Vincennes, IN | John A. Logan 53, Vincennes University 41 | Box score |
| 2/8/21 | Robinson, IL | Lincoln Trail 82, Vincennes University 79 | Box score |
| 2/3/21 | Vincennes, IN | Vincennes University 80, Lake Land 73 | Box score |
| 2/1/21 | Olney, IL | Olney Central 79, Vincennes University 70 | Box score |
| 1/30/21 | Vincennes, IN | Vincennes University 75, Kankakee 65 | Box score |
| 1/27/21 | Vincennes, IN | Vincennes University 80, Triton 67 | Box score |
| 1/23/21 | Vincennes, IN | Vincennes University 69, Highland 58 | Box score |
| 1/20/21 | Vincennes, IN | Vincennes University 83, Dohn Prep 66 | Box score |